創新療法和診斷
新研究：
胸腺胜肽在掉髮治療上之應用
源自胸腺具生物活性的胜肽之所以備受輔助醫療的重視，主要原因是它們具有恢復免疫力的特性，且經常可用於刺激人體自體免疫系統而在生病時產生B淋巴細胞和T淋巴細胞。雖然許多觀察和研究都已發現胸腺胜肽也可以成功應用於其他醫學相關領域，在知名期刊 Journal of Plastic Dermatology 最近發表的一項新研究中，再次證實胸腺胜肽在掉髮治療上的應用。
每個人頭上每天會掉約100根頭髮，但是因為髮根在正常狀況下會保留在頭皮上，所以可以重新生出新的頭髮。只有難以重生新髮的永久性掉髮，才能從外表上看出差異並且需要治療。靜止期掉髮（TE）和雄性禿（AGA）是掉髮的主要原因。AGA屬於高度擴散型病症，男性和女性皆可能受其影響。雄性禿的第一階段表現為發炎症狀所造成的頭髮稀疏。另一方面，慢性TE是幾乎只發生在女性身上的一種問題，影響因子有好幾種，特徵是大量掉髮，每天掉的頭髮超過100根，並且與慢性的發炎狀態有關。到目前為止的研究中，在一些病例中應用合成胸腺胜肽治療AGA和慢性TE已證實具臨床效果。
實驗設計和結果
本研究目的在測試低分子量胸腺胜肽（GKL係數）在第一階段雄性禿（AGA）和慢性靜止期掉髮（TE）在六個月中的有效性和適用性。本研究使用含有合成胸腺胜肽的胸腺胜肽養髮精華液和洗髮精（產品：Thymuskin ® /Fa. Klett-Loch GmbH）。
這項研究以深受掉髮病症之苦的337位病患（男性和女性皆有）進行試驗，掉髮病症屬慢性TE和第一階段AGA病症。第一組為第一階段AGA的70位男性，第二組為慢性TE的57位男性，第三組為第一階段AGA的53位女性，而第四組則為慢性TE的184位女性。
治療方案包括每日塗抹含有胸腺胜肽養髮精華液，以及每週使用3次洗髮精，為期24週。並針對所有測試對象進行拉扯測試和症狀評估（脂漏性皮膚炎、紅斑和搔癢）。在治療180天後，由醫師評估治療適用性和美妝接受度。
結果
在男性AGA患者中，94％在拉扯測試中有改善，89％在平均症狀有改善。TE患者中，98％在拉扯測試有改善、95％在平均症狀有改善。值得注意的是，在所有組中，100％的病例具正面適用性且無明顯副作用產生。98％病例顯示正面美妝接受度/耐受性。
摘要
本研究的目的在評估使用含有合成胸腺胜肽、天然材料（咖啡因、維生素E、異株蕁麻）和美妝原料（泛醇及植物性蛋白質）之產品（此指：Thymuskin®），在兩種經常發生發炎症狀的臨床情況中之有效性和適用性：第一階段AGA和慢性TE。在研究中使用該產品達到減緩掉髮、刺激頭髮生長之良好臨床反應。該治療還能改善經常伴隨這類病症出現的典型症狀，諸如紅斑、搔癢和脂漏性皮膚炎等。
作者：Forum Medizin Verlag編輯人員。聯絡電子信箱：medwiss@forum-medizin.de
參考文獻和書目
- Barbareschi M, Arena N et al.: Multicentric study of the effects of topical lotion and shampoo containing synthetic thymus peptides on androgenetic alopecia and chronic telogen effluvium in women and men. Journal of Plastic Dermatology. 2013: Vol.9 (2),
[1] C. Bolduc, J. Shapiro: Management of androgenetic alopecia. Am. J. Clin. Dermat. 2000; 1(3):151-8
[2] Renner D, Schuster D, Heim ME: Experiences using the ”thymuskin” hair cure for the prevention of alopecia in cytostatic treatment. Onkologie (1986) 5:285–6
[3] Sawaya ME, Shapiro J: Alopecia - unapproved treatments or indications. Clin Dermatol (2000) 18:177–86
[4] Donne Dermatologhe Italia (DDI). Clinical Investigation of the effects of topical lotion and shampoo containing synthetic thymus peptides on androgenetic and chronic telogen effluvium in women. J Plastic Dermatol 2008; 4:199-205.
資料提供：Naturheilkunde September / 2013
完整原文：
Innovative therapy and diagnostIcs
New Study:
The use of thymus peptides for hair loss
Biologically active peptides from the thymus gland are highly valued in complementary medicine, primarily because of their immunity restoring characteristics, and are commonly used to stimulate the body’s own immune system to produce B-lymphocytes and T-lymphocytes in the event of illness. However as numerous observations and studies have shown thymus peptides can also be used successfully in other medically relevant areas. A new study that was published recently in the renowned Journal of Plastic Dermatology confirms once again the therapeutic application of thymus peptides for hair loss.
Everybody loses approximately 100 hairs from their head everyday, whereby the hair roots normally remain in the scalp and can thus grow back. Only permanent hair loss, when lost hair is hardly replaced, is optically and therapeutically relevant. Telogen effluvium (TE) and androgenetic alopecia (AGA) are the main causes of hair loss. AGA is a highly diffuse illness that affects both men and women. In the first stages it presents as a thinning of the hair that is caused by inflammatory symptoms [1]. Chronic TE, on the other hand, is a disorder that almost exclusively occurs in women and that is caused by several factors; it is characterized by a relatively high level of hair loss of more than 100 hairs per day and can be associated with a chronic inflammatory state [2]. Investigations to date found a proven clinical effect in several cases [3-4] with synthetically manufactured thymus peptides in both AGA and chronic TE.
Study design and result
The objective of the investigation is to test the effectiveness and compatibility of thymus peptides with a low molecular weight (GKL factor) in the first phases of androgenetic alopecia (AGA) and in chronic telogen effluvium (TE) over a period of the six months. A thymus peptide lotion and a shampoo based on synthetic thymus peptides were used in this investigation (product: Thymuskin®/Fa. Klett-Loch GmbH).
The study was carried out with 337 patients (male and female) who were suffering from hair diseases, more precisely from chronic TE and the first stages of AGA. The first group comprised 70 male patients with the first stages of AGA and the second group comprised 57 male patients with chronic TE. The third group comprised 53 female patients with the first stages of AGA and the fourth and final group comprised 184 female patients with chronic TE.
The treatment plan included the application of the lotion every day and using the shampoo three times a week over a period of 24 weeks. A pull test and an evaluation of symptoms (sebhorrea, erythemes and itching) were carried out with all test subjects.
Doctors evaluated the compatibility and cosmetic acceptance after 180 days of treatment.
Results
Among the male AGA patients the pull test showed an improvement of 94% with an average improvement of symptoms of 89 %. Among the TE patients the improvement on the pull test was 98 % with an average improvement in symptoms of 95 %. 100% of cases in all groups reported positive compatibility and no side effects were noted. Positive cosmetic acceptance / tolerance was recorded in 98% of the cases.
Summary
The objective of the study was to evaluate the effectiveness and compatibility of a product (here: Thymuskin®) based on synthetic thymus peptides, natural substances (caffeine, vitamin E, urtica dioica) and cosmetic ingredients (panthenol and plant proteins) in two clinical situations: the first stages of AGA and chronic TE, which often occur together with inflammation symptoms. The product used in the study achieved good clinical reaction with a slowing of hair loss and stimulation of hair growth. The treatment was also able to improve typical symptoms that often accompany these forms of illness, such as erythemes, itching and seborrhoea.
Author: Editorial staff at Forum Medizin Verlag. Contact: medwiss@forum-medizin.de
Sources and bibliography
- Barbareschi M, Arena N et al.: Multicentric study of the effects of topical lotion and shampoo containing synthetic thymus peptides on androgenetic alopecia and
chronic telogen effluvium in women and men. Journal of Plastic Dermatology. 2013: Vol.9 (2),
[1] C. Bolduc, J. Shapiro: Management of androgenetic alopecia. Am. J. Clin. Dermat. 2000; 1(3):151-8
[2] Renner D, Schuster D, Heim ME: Experiences using the ‘‘thymu-skin’’ hair cure for the prevention of alopecia in cytostatic treatment. Onkologie (1986) 5:285–6
[3] Sawaya ME, Shapiro J: Alopecia – unapproved treatments or indications. Clin Dermatol (2000) 18:177–86
[4] Donne Dermatologhe Italia (DDI). Clinical Investigation of the effects of topical lotion and shampoo containing synthetic thymus peptides on androgenetic and chronic telogen effluvium in women. J Plastic Dermatol 2008; 4:199-205.
44 Die Naturheilkunde September/2013
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